By Feigal, Ellen G.
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Extra info for AIDS-Related Cancers and Their Treatment
However, at least in nodular lesions (which could represent Page 28 the moreadvanced form of this disease), the cells have now been shown to be clonal in origin (6), with lesions at different sites all derived from the same clone, which suggests metastasis (7). In areas without adequate medical care, such as parts of Africa, secondary infections and disability are major contributors to mortality, even when the cancer is considered to be the primary cause of death. In Mediterranean and eastern European areas, rates were threefold higher, about 1:100,000 persons, with persons of Jewish and perhaps also Arabic origin being at highest risk.
Incidence is higher when HLA types were imperfectly matched (79), suggesting that chronic antigenic stimulation might be important. Certainly, the specificity of some genetic and environmental associations, such as the 8:14 translocation in Burkitt's lymphoma and its association with EBV, argue that the molecular pathways promoting the growth of different NHL types are diverse. In addition, infection with EBV, a Bcell tropic virus, appears to be important in some tumors, perhaps by enhancing the development of immortalized B cells that are susceptible to malignant transformation.
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