Acromegaly: A Century of Scientific and Clinical Progress by Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins

By Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)

The manuscripts during this quantity have been contributed via the audio system invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The assembly was once geared up to commemorate the outline of acromegaly through the French health care professional Pierre Marie, in 1886. The contributors of the clinical Committee spent many hours aiding us in making sure a great assembly. The aid of Serono Symposia, united states in all stages of the making plans and execution of the assembly was once in actual fact favored and used to be hugely specialist. detailed popularity roust be prolonged to Professor Roger Guillemin of the Salk Institute, whosp curiosity in scientific background led him to dedicate loads of time and private cost in acquiring information regarding the lifetime of Pierre Marie. Dr. GuilIemin's presentation at the lifestyles and instances of Marie used to be a rare review of the cultural, social, and medical backgrounds during which Marie got here to explain the sickness, acromegaly. Dr. Guillemin' s findings, that have been awarded on the major dinner party in a the best option audiovisual presentation, have been sincerely the spotlight of the assembly and should lengthy be remembered through the attendees. We have been additionally venerated by means of the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her handle on the dinner party, Dr. Granier supplied numerous pleasant and intimate vignettes bearing on Pierre Marie, utilizing previous kinfolk documents and images. The clinical Committee needs to increase its gratitude to Dr. Granier for including immeasurably to the old surroundings of the meeting.

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Miami winter symposium. New York: Academic Press, 1980. Lewis UJ, Peterson SM, Bonewald LF, Seavey BK, VanderLaan WP. An interchain disulfide dimer of human growth hormone. J BioI Chem 1977; 252:3697. Schneider AB, Kowalski K, Russell J, Sherwood LM. Identification of the interchain disulfide bonds of dimeric human placental lactogen. J BioI Chem 1979; 254:3782. DeNoto FM, Moore DD, Goodman HM. Human growth hormone DNA sequence and mRNA structure: possible alternative splicing. Nucleic Acids Res 1981; 9:3719.

Wurzel J, Parks JS, Herd JE, et al. A gene deletion is responsible for absence of human chorionic somatomammotropin. DNA 1982; 1:251. 42. Parks JS. Organization and function of the growth hormone gene cluster. In: Raiti S, Tolman RA, eds. Human growth hormone. New York: Plenum, 1986:199. 43. Pavlakis GN, Hizuka N, Gorden P, et al. Expression of two human growth hormone genes in monkey cells infected by simian virus 40 recombinants. Proc Natl Acad Sci USA 1981; 78:7398. 44. Hizuka N, Hendricks CM, Pavlakis GN, et al.

The possibility exists, therefore, that when given to an animal, GH is cleaved either in the circulation or at the target organ to produce a diabetogenic fragment more active than GH itself. Evidence for another diabetogenic 31 substance also comes from the report by Hart et al. (40) who showed that a preparation of bovine GH with the greatest growth promoting activity was not the most diabetogenic fraction isolated from the pituitary. Another pituitary fraction rich in low molecular weight substances showed the greatest diabetogenic activity.

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